BIOAVAILABILITY OF β-ADRENOCEPTOR BLOCKING DRUGS

Pharmacological properties of beta-adrenoceptor blocking drugs

Beta-adrenoceptor-blocking drugs, growth hormone and acromegaly.

Chronic treatment with oxprenolol or propranolol in active hypertensive patients was associated with elevation of serum growth hormone (GH). Propranolol, 80 mg orally, caused a marked rise in GH in 3 of 4 acromegalic patients.

Effect of Some Adrenoceptor Activating and Blocking Drugs on Response of Fish Melanophores

The fresh water Indian neopterigian teleost, Cyprinuscarpio, a common carp deals with some aspect concerning chromatic regulatory mechanisms, within the boundary of the two points of view: one of these is the value of colour pattern, as signals to other animals for the purpose of recognition, stimulation or warning or for the purpose of concealment of predator of prey. In this field is included...

THE SELECTIVE ACTION OF /B-ADRENOCEPTOR BLOCKING DRUGS AND THE NATURE OF /3l and /2 ADRENOCEPTORS

1 Purified membranes retaining a catecholamine responsive adenylate cyclase have been prepared from rabbit heart, lung and (pseudo-pregnant) uterus. 2 These preparations have the characteristics of plasma membranes and both heart and lung respond to P-adrenoceptor agonists in the order: (± )-isoprenaline > (-)-noradrenaline > (-)-adrenaline > ( + )-isoprenaline > salbutamol. The sensitivity of ...

Action of several -adrenoceptor blocking drugs in the pregnant sheep and foetus.

1. The effect of several beta-adrenoceptor blocking drugs on the pregnant ewe and foetus were studied. Bunolol, butidrine, oxprenolol, propranolol and USVP65-24 all crossed the ovine placenta and produced a beta-adrenoceptor blockade in the ovine foetus. AH3474, AY21011 and sotalol did not cross the ovine placenta as assessed by the absence of a beta-blockade in the foetus when these compounds ...